Nevo melanocítico congénito gigante: presentación de tres casos / Giants congenital melanocytic nevus: Report of three cases

Los Nevos Melanocíticos Congénitos (NMC) son lesiones pigmentarias, que pueden aparecer en el nacimiento, aunque hay casos comunicados hasta el primer año de vida (Nevo Melanocítico Congénito Tardío). Presentan ciertas características clínicas y evolutivas de gran importancia: el compromiso estético de las formas gigantes, la asociación con melanocitosis meníngea y su transformación maligna de la lesión cutánea o meníngea. Presentamos tres casos de nevos melanocíticos congénitos gigantes. Cabe destacar, que el objetivo de este artículo es realizar una revisión del tema, orientar al seguimiento y control de los mismos y destacar la dificultad para su tratamiento debido a su gran tamaño.

The Congenital Melanocytic Nevus are lesions melanocytic pigmented. Already apparent at birth but there are cases reported to the first year of life (Late Congenital Melanocytic Nevus). Certain features and evolution clinics that are important: the great compromise of aesthetic forms giant, meningeal melanocitosis association and its malignant transformation. We present three cases of Giants Congenital Melanocytic Nevus. It should be noted, that the purpose of this article is a review of the issue and guide the monitoring and control of them and point out the difficult treatment.

Serie de paciente con escabiosis tratados con azufre precipitado al 6% / Series of patient with scabies treated with 6% precipitated sulfur

OBJETIVOS: reportar los resultados de la estrategia que incluye "el tratamiento tópico con azufre precipitado al 6% sumado a medidas no farmacológicas" en la población de Villa Verde, Pilar, Buenos Aires, Argentina. MÉTODOS: Serie de casos tratados entre Marzo de 2007 y marzo de 2008 de una muestra de conveniencia integrada por toda la población con signos y síntomas sugestivos de escabiosis durante dicho período. RESULTADOS: Fueron incluidos 161 pacientes, pero sólo se pudo realizar la evaluación completa en 110 de ellos (68,3%). De éstos, 74 se encontraba curado a los 15 días de iniciado el tratamiento y otros 23, al mes, lo que implica una tasa global de curación de 88%. Sólo 12,7% de la muestra evaluada presentó efectos adversos. El 20% de los encuestados percibió la intervención como de bajo costo, el 32,6 de costo moderado y el 47,5 alto. El autorreporte de adherencia al tratamiento farmacológico fue de 95% y del no farmacológico, 96%. CONCLUSIONES: Estos resultados contribuyen a avalar una estrategia terapéutica ampliamente utilizada en nuestro medio (por su bajo precio y amplia disponibilidad), que por el momento posee escasa evidencia científica y es utilizada por motivos fundamentalmente empíricos.

OBJECTIVES: Report the results of the strategy that includes "the topical treatment with precipitated sulfur at 6% plus non-pharmacological measures" in the population of Villa Verde, Pilar, Buenos Aires, Argentina. METHODS: A series of cases treated between March 2007 and March 2008 of a sample of convenience integrated by the entire population with signs and symptoms suggestive of scabies during this period. RESULTS: A total of 161 patients were included, but only 110 of them could complete the complete evaluation (68.3%). Of these, 74 were cured 15 days after starting treatment and another 23, a month, which implies an overall cure rate of 88%. Only 12.7% of the sample evaluated had adverse effects. 20% of respondents perceived the intervention as low cost, 32.6 moderate cost and 47.5 high. Self-reported adherence to pharmacological treatment was 95% and non-pharmacological self-report was 96%. CONCLUSIONS: These results contribute to endorse a therapeutic strategy widely used in our environment (due to its low price and wide availability), which at the moment has little scientific evidence and is used for fundamentally empirical reasons.

Effect of dietary fat saturation on lipid metabolism, arachidonic acid turnover and peritoneal macrophage oxidative stress in mice

We investigated the effects of a saturated fat diet on lipid metabolism and arachidonic acid (AA) turnover in mouse resident peritoneal macrophages. The pro-oxidative effect of this diet was also studied. Female C57BL/6 mice were weaned at 21 days of age and assigned to either the experimental diet containing coconut oil (COCO diet), or the control diet containing soybean oil as fat source (10 mice per group). The fat content of each diet was 15 percent (w/w). Mice were fed for 6 weeks and then sacrificed. The concentration of total lipids, triglycerides, (LDL + VLDL)-cholesterol, thiobarbituric acid-reactive substances (TBARS) and reduced glutathione were increased in the plasma of mice fed the COCO diet, without changes in phospholipid or total cholesterol concentrations compared to control. The concentrations of total cholesterol, free and esterified cholesterol, triglycerides, and TBARS were increased in the macrophages of COCO-fed mice, while the content of total phospholipids did not change. The phospholipid composition showed an increase of phosphatidylcholine and a decrease of phosphatidylethanolamine. The [ H]-AA distribution in the phospholipid classes showed an increase in phosphatidylcholine and phosphatidylethanolamine. Incorporation of [ H]-cholesterol into the macrophages of COCO-fed mice and into the cholesterol ester fraction was increased. The COCO diet did not affect [ H]-AA uptake but induced an increase in [ H]-AA release. The COCO diet also enhanced AA mobilization induced by lipopolysaccharide. These results indicate that the COCO diet, high in saturated fatty acids, alters the lipid metabolism and AA turnover of peritoneal macrophages in female mice and also produces a significant degree of oxidative stress.